Pet Imaging Agents for the Differential Diagnosis of Hypoxic Tumors

Fluorine-18 radiolabeling of a nitrophenyl sulfoxide and its evaluation in an SK-RC-52 model of tumor hypoxia

E Laurens, SD Yeoh, A Rigopoulos, GJ O'Keefe, HJ Tochon-Danguy, LW Chong, JM White, AM Scott, U Ackermann

2016-08-01

The significance of imaging hypoxia with the positron emission tomography ligand [¹⁸F]FMISO has been demonstrated in a ..

Toward Hypoxia-Selective Rhenium and Technetium Tricarbonyl Complexes

AJ North, DJ Hayne, C Schieber, K Price, AR White, PJ Crouch, A Rigopoulos, GJ OKeefe, H Tochon-Danguy, AM Scott, JM White, U Ackermann, PS Donnelly

2015-10-05

With the aim of preparing hypoxia-selective imaging and therapeutic agents, technetium(I) and rhenium(I) tricarbonyl complexes wit..

A Versatile Approach for the Site‐Specific Modification of Recombinant Antibodies Using a Combination of Enzyme‐Mediated Bioconjugation and Click Chemistry

Karen Alt, Brett M Paterson, Erik Westein, Stacey E Rudd, Stan S Poniger, Shweta Jagdale, Katie Ardipradja, Timothy U Connell, Guy Y Krippner, Ashish KN Nair, Xiaowei Wang, Henri J Tochon‐Danguy, Paul S Donnelly, Karlheinz Peter, Christoph E Hagemeyer

2015-06-22

<jats:title>Abstract</jats:title><jats:p>A unique two‐step modular system for site‐specific antibody modification and conjugation ..

A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry

K Alt, BM Paterson, E Westein, SE Rudd, SS Poniger, S Jagdale, K Ardipradja, TU Connell, GY Krippner, AKN Nair, X Wang, HJ Tochon-Danguy, PS Donnelly, K Peter, CE Hagemeyer

2015-06-01

A unique two-step modular system for site-specific antibody modification and conjugation is reported. The first step of this appro..

Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets

K Alt, BM Paterson, K Ardipradja, C Schieber, G Buncic, B Lim, SS Poniger, B Jakoby, X Wang, GJ Okeefe, HJ Tochon-Danguy, AM Scott, U Ackermann, K Peter, PS Donnelly, CE Hagemeyer

2014-08-04

Imaging of activated platelets using an activation specific anti-GPIIb/IIIa integrin single-chain antibody (scFv<inf>anti-LIBS</in..

Detection of activated platelets in a mouse model of carotid artery thrombosis with 18F-labeled single-chain antibodies

K Ardipradja, SD Yeoh, K Alt, G O'Keefe, A Rigopoulos, DW Howells, AM Scott, K Peter, U Ackerman, CE Hagemeyer

2014-03-01

Introduction: Activated platelets are key players in thrombosis and inflammation. We previously generated single-chain antibodies ..

Fully automated synthesis and coupling of [18F]FBEM to glutathione using the iPHASE FlexLab module

U Ackermann, L Plougastel, C Wichmann, YW Goh, SD Yeoh, SS Poniger, HJ Tochon-Danguy, AM Scott

2014-01-01

Site-specific radiolabelling of peptides or antibodies using [ ¹⁸F]FBEM is often preferred over non-site-specific radio..

Improved synthesis of [18F]FLETT via a fully automated vacuum distillation method for [18F]2-fluoroethyl azide purification

U Ackermann, L Plougastel, YW Goh, SD Yeoh, AM Scott

2014-01-01

The synthesis of [¹⁸F]2-fluoroethyl azide and its subsequent click reaction with 5-ethynyl-2'-deoxyuridine (EDU) to for..

Radiolabelling and evaluation of a novel sulfoxide as a PET imaging agent for tumor hypoxia

E Laurens, SD Yeoh, A Rigopoulos, D Cao, GA Cartwright, GJ O'Keefe, HJ Tochon-Danguy, JM White, AM Scott, U Ackermann

2014-01-01

[¹⁸F]FMISO is the most widely validated PET radiotracer for imaging hypoxic tissue. However, as a result of the pharmac..

Synthesis of 2-[(4-[18F]Fluorobenzoyloxy)methyl]-1,4- naphthalenedione from 2-hydroxymethyl 1,4-naphthoquinone and 4-[ 18F]fluorobenzoic acid using dicyclohexyl carbodiimide

U Ackermann, D Sigmund, SD Yeoh, A Rigopoulos, G O'Keefe, G Cartwright, J White, AM Scott, HJ Tochon-Danguy

2011-01-01

2-[(4-[¹⁸F]Fluorobenzoyloxy)methyl]-1,4-naphthalenedione ([ ¹⁸F]1) was synthesised as a putative hypoxia ima..